PDBsum entry 3v0x

Hydrolase/hydrolase inhibitor

PDB id: 3v0x

Contents

Protein chain

223 a.a.

Ligands

ANH

GOL

Metals

_CA

Waters ×169

PDB id:

3v0x

Name:

Hydrolase/hydrolase inhibitor

Title:

Bovine trypsin variant x(tripleglu217phe227) in complex with small molecule inhibitor

Structure:

Cationic trypsin. Chain: a. Synonym: beta-trypsin, alpha-trypsin chain 1, alpha-trypsin chain 2. Engineered: yes. Mutation: yes

Source:

Bos taurus. Bovine. Organism_taxid: 9913. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

1.90Å R-factor: 0.165 R-free: 0.207

Authors:

A.Tziridis,P.Neumann,P.Kolenko,M.T.Stubbs

Key ref:

A.Tziridis et al. Bovine trypsin variants X(tripleglu217phe227) in comp with small molecule inhibitor. To be published, .

Date:

09-Dec-11 Release date: 12-Dec-12

Protein chain

P00760  (TRY1_BOVIN) -  Serine protease 1 from Bos taurus

Seq: 246 a.a.

Struc: 223 a.a.*

* PDB and UniProt seqs differ at 11 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.3.4.21.4 - trypsin.
• Reaction: Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.