PDBsum entry 3uw3

Oxidoreductase

PDB id

3uw3

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Contents

			Protein chains

					374 a.a.

			Ligands

					EDO ×2

			Waters ×860

PDB id:

3uw3

Links

Name:

Oxidoreductase

Title:

Crystal structure of an aspartate-semialdehyde dehydrogenase from burkholderia thailandensis

Structure:

Aspartate-semialdehyde dehydrogenase. Chain: a, b. Engineered: yes

Source:

Burkholderia thailandensis. Organism_taxid: 271848. Strain: e264 / atcc 700388 / dsm 13276 / cip 106301. Gene: asd, bth_ii0675. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

1.55Å

R-factor:

0.152

R-free:

0.173

Authors:

Seattle Structural Genomics Center For Infectious Disease (Ssgcid)

Key ref:

L.Baugh et al. (2013). Combining functional and structural genomics to sample the essential Burkholderia structome. Plos One, 8, e53851. PubMed id: 23382856

Date:

30-Nov-11

Release date:

14-Dec-11

PROCHECK

	Headers

	References

Protein chains

Q2T7H5 (Q2T7H5_BURTA) - Aspartate-semialdehyde dehydrogenase from Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264)

Seq: Struc:					373 a.a. 374 a.a.

Key:

PfamA domain

Secondary structure

CATH domain



		Enzyme reactions

Enzyme class:

E.C.1.2.1.11 - aspartate-semialdehyde dehydrogenase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Pathway:

Lysine biosynthesis (early stages)

Reaction:

L-aspartate 4-semialdehyde + phosphate + NADP⁺ = 4-phospho-L-aspartate + NADPH + H⁺

L-aspartate 4-semialdehyde	+	phosphate	+	NADP(+)	=	4-phospho-L-aspartate	+	NADPH	+	H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

	Plos One 8:e53851 (2013)
PubMed id: 23382856

Combining functional and structural genomics to sample the essential Burkholderia structome.
L.Baugh, L.A.Gallagher, R.Patrapuvich, M.C.Clifton, A.S.Gardberg, T.E.Edwards, B.Armour, D.W.Begley, S.H.Dieterich, D.M.Dranow, J.Abendroth, J.W.Fairman, D.Fox, B.L.Staker, I.Phan, A.Gillespie, R.Choi, S.Nakazawa-Hewitt, M.T.Nguyen, A.Napuli, L.Barrett, G.W.Buchko, R.Stacy, P.J.Myler, L.J.Stewart, C.Manoil, W.C.Van Voorhis.

ABSTRACT

No abstract given.