PDBsum entry 3ukk

Isomerase

PDB id

3ukk

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Contents

			Protein chains

					517 a.a.

			Ligands

					FDA ×3


					UDP ×4


					FAD

			Waters ×172

PDB id:

3ukk

Links

Name:

Isomerase

Title:

Crystal structure of r182k-udp-galactopuranose mutase from aspergillus fumigatus in complex with udpgalp

Structure:

Udp-galactopyranose mutase. Chain: a, b, c, d. Engineered: yes. Mutation: yes

Source:

Aspergillus fumigatus. Organism_taxid: 746128. Strain: csb 144-89. Gene: glf, glfa. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

2.75Å

R-factor:

0.186

R-free:

0.241

Authors:

K.E.Van Straaten,D.A.R.Sanders

Key ref:

K.E.van Straaten et al. (2012). Structural insight into the unique substrate binding mechanism and flavin redox state of UDP-galactopyranose mutase from Aspergillus fumigatus. J Biol Chem, 287, 10780-10790. PubMed id: 22334662

Date:

09-Nov-11

Release date:

22-Feb-12

PROCHECK

	Headers

	References

Protein chains

Q4W1X2 (GLFA_ASPFM) - UDP-galactopyranose mutase from Aspergillus fumigatus

Seq: Struc:					510 a.a. 517 a.a.*

Key:

PfamA domain

Secondary structure

CATH domain

* PDB and UniProt seqs differ at 1 residue position (black cross)



		Enzyme reactions

Enzyme class:

E.C.5.4.99.9 - UDP-galactopyranose mutase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Pathway:

UDP-glucose, UDP-galactose and UDP-glucuronate Biosynthesis

Reaction:

UDP-alpha-D-galactose = UDP-alpha-D-galactofuranose

UDP-D-galactopyranose	=	UDP-D-galacto-1,4-furanose

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

	J Biol Chem 287:10780-10790 (2012)
PubMed id: 22334662

Structural insight into the unique substrate binding mechanism and flavin redox state of UDP-galactopyranose mutase from Aspergillus fumigatus.
K.E.van Straaten, F.H.Routier, D.A.Sanders.

ABSTRACT

No abstract given.