PDBsum entry 3ujc

Transferase

PDB id: 3ujc

Contents

Protein chain

258 a.a.

Ligands

_PC

Waters ×498

PDB id:

3ujc

Name:

Transferase

Title:

Phosphoethanolamine methyltransferase mutant (h132a) from plasmodium falciparum in complex with phosphocholine

Structure:

Phosphoethanolamine n-methyltransferase. Chain: a. Engineered: yes

Source:

Plasmodium falciparum. Organism_taxid: 5833. Gene: pmt. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.19Å R-factor: 0.146 R-free: 0.167

Authors:

S.G.Lee,Y.Kim,T.D.Alpert,A.Nagata,J.M.Jez

Key ref:

S.G.Lee et al. (2012). Structure and reaction mechanism of phosphoethanolamine methyltransferase from the malaria parasite Plasmodium falciparum: an antiparasitic drug target. J Biol Chem, 287, 1426-1434. PubMed id: 22117061

Date:

07-Nov-11 Release date: 30-Nov-11

Protein chain

Q8IDQ9  (Q8IDQ9_PLAF7) -  Phosphoethanolamine N-methyltransferase from Plasmodium falciparum (isolate 3D7)

Seq: 266 a.a.

Struc: 259 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.2.1.1.103 - phosphoethanolamine N-methyltransferase.
• Reaction: phosphoethanolamine + S-adenosyl-L-methionine = N-methylethanolamine phosphate + S-adenosyl-L-homocysteine + H⁺

phosphoethanolamine + S-adenosyl-L-methionine = N-methylethanolamine phosphate + S-adenosyl-L-homocysteine (Bound ligand (Het Group name = PC) matches with 81.82% similarity) + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

J Biol Chem 287:1426-1434 (2012)

PubMed id: 22117061

Structure and reaction mechanism of phosphoethanolamine methyltransferase from the malaria parasite Plasmodium falciparum: an antiparasitic drug target.

S.G.Lee, Y.Kim, T.D.Alpert, A.Nagata, J.M.Jez.

ABSTRACT

No abstract given.