PDBsum entry 3u3a

Lyase

PDB id: 3u3a

Contents

Protein chain

258 a.a.

Ligands

GOL ×2

Metals

_ZN

Waters ×248

PDB id:

3u3a

Name:

Lyase

Title:

Structure of human carbonic anhydrase ii v143i

Structure:

Carbonic anhydrase 2. Chain: x. Synonym: carbonate dehydratase ii, carbonic anhydrasE C, cac, carbonic anhydrase ii, ca-ii. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ca2, hca2. Expressed in: escherichia coli. Expression_system_taxid: 511693.

Resolution:

1.55Å R-factor: 0.163 R-free: 0.191

Authors:

D.West,R.Mckenna

Key ref:

D.West et al. Structural analysis of human carbonic anhydrase ii bi pocket. To be published, .

Date:

05-Oct-11 Release date: 10-Oct-12

Protein chain

P00918  (CAH2_HUMAN) -  Carbonic anhydrase 2 from Homo sapiens

Seq: 260 a.a.

Struc: 258 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class 2: E.C.4.2.1.1 - carbonic anhydrase.
• Reaction: hydrogencarbonate + H⁺ = CO2 + H2O
• Cofactor: Zn(2+)
• Enzyme class 3: E.C.4.2.1.69 - cyanamide hydratase.
• Reaction: urea = cyanamide + H2O

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site