PDBsum entry 3th4

Hydrolase/hydrolase inhibitor

PDB id: 3th4

Contents

Protein chains

142 a.a.

254 a.a.

191 a.a.

Ligands

BGC

FUC

0GE

Metals

_CL ×3

_MG ×2

_CA ×7

_NA

Waters ×383

PDB id:

3th4

Name:

Hydrolase/hydrolase inhibitor

Title:

Mg2+ is required for optimal folding of the gamma-carboxyglutamic acid (gla) domains of vitamin k-dependent clotting factors at physiological ca2+

Structure:

Coagulation factor vii light chain. Chain: l. Synonym: proconvertin, serum prothrombin conversion accelerator, spca. Coagulation factor vii heavy chain. Chain: h. Synonym: proconvertin, serum prothrombin conversion accelerator, spca. Tissue factor.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Other_details: blood. Other_details: blood

Resolution:

1.80Å R-factor: 0.206 R-free: 0.235

Authors:

K.Vadivel,S.Agah,D.Cascio,K.Padmanabhan,S.P.Bajaj

Key ref:

K.Vadivel et al. Mg2+ is required for optimal folding of the gamma-Carboxyglutamic acid (gla) domains of vitamin k-Dependent clotting factors at physiological ca2+. To be published, .

Date:

18-Aug-11 Release date: 22-Aug-12

Protein chain

P08709  (FA7_HUMAN) -  Coagulation factor VII from Homo sapiens

Seq: 466 a.a.

Struc: 142 a.a.*

Protein chain

P08709  (FA7_HUMAN) -  Coagulation factor VII from Homo sapiens

Seq: 466 a.a.

Struc: 254 a.a.

Protein chain

P13726  (TF_HUMAN) -  Tissue factor from Homo sapiens

Seq: 295 a.a.

Struc: 191 a.a.

* PDB and UniProt seqs differ at 10 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chains L, H: E.C.3.4.21.21 - coagulation factor VIIa.
• Reaction: Hydrolyzes one Arg-|-Ile bond in factor X to form factor Xa.