PDBsum entry 3sw4

Transferase/transferase inhibitor

PDB id: 3sw4

Contents

Protein chain

281 a.a.

Ligands

18K

ACT

Waters ×143

PDB id:

3sw4

Name:

Transferase/transferase inhibitor

Title:

Crystal structure of the cdk2 in complex with thiazolylpyrimidine inhibitor

Structure:

Cyclin-dependent kinase 2. Chain: a. Synonym: cell division protein kinase 2, p33 protein kinase. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high-five.

Resolution:

1.70Å R-factor: 0.185 R-free: 0.208

Authors:

Y.N.Kang,J.A.Stuckey

Key ref:

Y.N.Kang and j.a.stuckey Crystal structure of the cdk2 in complex with a thiazolylpyrimidine inhibitor. To be published, .

Date:

13-Jul-11 Release date: 01-Aug-12

Protein chain

P24941  (CDK2_HUMAN) -  Cyclin-dependent kinase 2 from Homo sapiens

Seq: 298 a.a.

Struc: 280 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.11.22 - cyclin-dependent kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site