PDBsum entry 3sw3

Hydrolase

PDB id: 3sw3

Contents

Protein chain

205 a.a.

Waters ×110

PDB id:

3sw3

Name:

Hydrolase

Title:

Edta-free crystal structure of the mutant c221d of carbapenemase cpha from aeromonas hydrophila

Structure:

Beta-lactamase. Chain: a. Fragment: unp residues 28-254. Synonym: carbapenemase cpha. Engineered: yes. Mutation: yes

Source:

Aeromonas hydrophila. Organism_taxid: 644. Gene: cpha. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

2.35Å R-factor: 0.192 R-free: 0.261

Authors:

H.Delbruck,K.M.V.Hoffmann

Key ref:

H.Delbruck et al. Edta-Free crystal structure of the mutant c221d of carbapenemase cpha from aeromonas hydrophila. To be published, .

Date:

13-Jul-11 Release date: 18-Jul-12

Protein chain

P26918  (BLAB_AERHY) -  Metallo-beta-lactamase type 2 from Aeromonas hydrophila

Seq: 254 a.a.

Struc: 205 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.3.5.2.6 - beta-lactamase.
• Pathway: Penicillin Biosynthesis and Metabolism
• Reaction: a beta-lactam + H2O = a substituted beta-amino acid
• Cofactor: Zn(2+)