PDBsum entry 3svm

Transferase

PDB id: 3svm

Contents

Protein chains

60 a.a.

12 a.a.

Waters ×24

PDB id:

3svm

Name:

Transferase

Title:

Human mpp8 - human dnmt3ak47me2 peptide

Structure:

M-phase phosphoprotein 8. Chain: a. Fragment: unp residues 55-116. Synonym: two hybrid-associated protein 3 with ranbpm, twa3. Engineered: yes. DNA (cytosine-5)-methyltransferase 3a. Chain: p. Fragment: unp residues 40-53. Synonym: dnmt3a, DNA methyltransferase hsaiiia, DNA mtase hsaiiia,

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: mphosph8, mpp8. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606

Resolution:

2.31Å R-factor: 0.257 R-free: 0.272

Authors:

Y.Chang,J.R.Horton,X.Zhang,X.Cheng

Key ref:

Y.Chang et al. (2011). MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a. Nat Commun, 2, 533-533. PubMed id: 22086334

Date:

12-Jul-11 Release date: 30-Nov-11

Protein chain

Q99549  (MPP8_HUMAN) -  M-phase phosphoprotein 8 from Homo sapiens

Seq: 860 a.a.

Struc: 60 a.a.

Protein chain

Q9Y6K1  (DNM3A_HUMAN) -  DNA (cytosine-5)-methyltransferase 3A from Homo sapiens

Seq: 912 a.a.

Struc: 12 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain P: E.C.2.1.1.37 - Dna (cytosine-5-)-methyltransferase.
• Reaction: a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl- 2'-deoxycytidine in DNA + S-adenosyl-L-homocysteine + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

Nat Commun 2:533-533 (2011)

PubMed id: 22086334

MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a.

Y.Chang, L.Sun, K.Kokura, J.R.Horton, M.Fukuda, A.Espejo, V.Izumi, J.M.Koomen, M.T.Bedford, X.Zhang, Y.Shinkai, J.Fang, X.Cheng.

ABSTRACT

No abstract given.