PDBsum entry 3so6

Protein binding/protein transport

PDB id: 3so6

Contents

Protein chains

137 a.a.

13 a.a.

Waters ×185

PDB id:

3so6

Name:

Protein binding/protein transport

Title:

Crystal structure of the ldl receptor tail in complex with autosomal recessive hypercholesterolemia ptb domain

Structure:

Ldl receptor adaptor protein. Chain: a. Fragment: unp residues 43-174. Engineered: yes. Low-density lipoprotein receptor. Chain: q. Fragment: unp residues 817-832. Synonym: ldl receptor. Engineered: yes

Source:

Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: ldlrap1, rgd1563417_predicted, rcg_31034. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Homo sapiens. Human.

Resolution:

1.37Å R-factor: 0.154 R-free: 0.206

Authors:

H.Dvir,D.M.Zajonc

Key ref:

H.Dvir et al. (2012). Atomic structure of the autosomal recessive hypercholesterolemia phosphotyrosine-binding domain in complex with the LDL-receptor tail. Proc Natl Acad Sci U S A, 109, 6916-6921. PubMed id: 22509010

Date:

29-Jun-11 Release date: 18-Apr-12

Protein chain

D3ZAR1  (ARH_RAT) -  Low density lipoprotein receptor adapter protein 1 from Rattus norvegicus

Seq: 306 a.a.

Struc: 137 a.a.*

Protein chain

P01130  (LDLR_HUMAN) -  Low-density lipoprotein receptor from Homo sapiens

Seq: 860 a.a.

Struc: 13 a.a.

* PDB and UniProt seqs differ at 7 residue positions (black crosses)

Proc Natl Acad Sci U S A 109:6916-6921 (2012)

PubMed id: 22509010

Atomic structure of the autosomal recessive hypercholesterolemia phosphotyrosine-binding domain in complex with the LDL-receptor tail.

H.Dvir, M.Shah, E.Girardi, L.Guo, M.G.Farquhar, D.M.Zajonc.

ABSTRACT

No abstract given.