PDBsum entry 3sfc

Hydrolase/hydrolase inhibitor

PDB id: 3sfc

Contents

Protein chain

340 a.a.

Ligands

NAG ×2

GOL ×4

S53 ×3

Waters ×483

PDB id:

3sfc

Name:

Hydrolase/hydrolase inhibitor

Title:

Structure-based optimization of potent 4- and 6-azaindole-3- carboxamides as renin inhibitors

Structure:

Renin. Chain: a, b. Fragment: unp residues 67-406. Synonym: angiotensinogenase. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek

Resolution:

2.10Å R-factor: 0.212 R-free: 0.243

Authors:

B.Scheiper,H.Matter,H.Steinhagen,Z.Bocskei,V.Fleury,G.Mccort

Key ref:

B.Scheiper et al. (2011). Structure-based optimization of potent 4- and 6-azaindole-3-carboxamides as renin inhibitors. Bioorg Med Chem Lett, 21, 5480-5486. PubMed id: 21840218

Date:

13-Jun-11 Release date: 31-Aug-11

Protein chains

P00797  (RENI_HUMAN) -  Renin from Homo sapiens

Seq: 406 a.a.

Struc: 340 a.a.

Enzyme reactions

• Enzyme class: E.C.3.4.23.15 - renin.
• Reaction: Cleaves Leu-|- bond in angiotensinogen to generate angiotensin I.

Bioorg Med Chem Lett 21:5480-5486 (2011)

PubMed id: 21840218

Structure-based optimization of potent 4- and 6-azaindole-3-carboxamides as renin inhibitors.

B.Scheiper, H.Matter, H.Steinhagen, Z.Böcskei, V.Fleury, G.McCort.

ABSTRACT

No abstract given.