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PDBsum entry 3s8s
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Transcription
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PDB id
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3s8s
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PDB id:
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| Name: |
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Transcription
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Title:
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Crystal structure of the rrm domain of human setd1a
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Structure:
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Histone-lysine n-methyltransferase setd1a. Chain: a. Synonym: lysine n-methyltransferase 2f, set domain-containing protein 1a, hset1a, set1/ash2 histone methyltransferase complex subunit set1. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: setd1a, kiaa0339, kmt2f, set1, set1a. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Resolution:
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1.30Å
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R-factor:
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0.170
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R-free:
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0.198
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Authors:
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X.Chao,W.Tempel,C.Bian,T.Cerovina,J.R.Walker,C.Bountra,J.Weigelt, C.H.Arrowsmith,A.M.Edwards,J.Min,Structural Genomics Consortium (Sgc)
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Key ref:
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X.Chao
et al.
Crystal structure of the rrm domain of human setd1a.
To be published,
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Date:
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30-May-11
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Release date:
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08-Jun-11
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PROCHECK
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Headers
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References
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O15047
(SET1A_HUMAN) -
Histone-lysine N-methyltransferase SETD1A from Homo sapiens
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Seq:
Struc:
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1707 a.a.
107 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.2.1.1.364
- [histone H3]-lysine(4) N-methyltransferase.
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Reaction:
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L-lysyl4-[histone H3] + S-adenosyl-L-methionine = N6-methyl-L- lysyl4-[histone H3] + S-adenosyl-L-homocysteine + H+
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L-lysyl(4)-[histone H3]
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+
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S-adenosyl-L-methionine
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=
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N(6)-methyl-L- lysyl(4)-[histone H3]
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+
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S-adenosyl-L-homocysteine
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
