PDBsum entry 3ror

Hydrolase

PDB id: 3ror

Contents

Protein chain

282 a.a.

Ligands

BME

Metals

_CO ×2

__K

Waters ×56

PDB id:

3ror

Name:

Hydrolase

Title:

Crystal structure of c105s mutant of mycobacterium tuberculosis methionine aminopeptidase

Structure:

Methionine aminopeptidase. Chain: a. Synonym: map, peptidase m. Engineered: yes. Mutation: yes

Source:

Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: map, mapb, metap, mt2929, mtv003.07c, rv2861c. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.00Å R-factor: 0.214 R-free: 0.274

Authors:

R.Reddi,C.Kishor,A.Addlagatta

Key ref:

R.Reddi et al. Crystal structure of c105s mutant of mycobacterium tuberculosis methionine aminopeptidase. To be published, .

Date:

26-Apr-11 Release date: 23-May-12

Protein chain

P9WK19  (MAP12_MYCTU) -  Methionine aminopeptidase 2 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

Seq: 285 a.a.

Struc: 282 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.3.4.11.18 - methionyl aminopeptidase.
• Reaction: Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
• Cofactor: Cobalt cation