PDBsum entry 3rgo

Hydrolase

PDB id: 3rgo

Contents

Protein chain

157 a.a.

Ligands

SO4 ×2

Waters ×48

PDB id:

3rgo

Name:

Hydrolase

Title:

Crystal structure of ptpmt1

Structure:

Protein-tyrosine phosphatase mitochondrial 1. Chain: a. Synonym: pten-like phosphatase, phosphoinositide lipid phosphatase. Engineered: yes

Source:

Mus musculus. Mouse. Organism_taxid: 10090. Gene: plip, ptpmt1. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.93Å R-factor: 0.228 R-free: 0.243

Authors:

J.Xiao,J.L.Engel

Key ref:

J.Xiao et al. (2011). Structural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesis. Proc Natl Acad Sci U S A, 108, 11860-11865. PubMed id: 21730175

Date:

08-Apr-11 Release date: 06-Jul-11

Protein chain

Q66GT5  (PTPM1_MOUSE) -  Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 from Mus musculus

Seq: 193 a.a.

Struc: 157 a.a.

Enzyme reactions

• Enzyme class 2: E.C.3.1.3.16 - protein-serine/threonine phosphatase.
• Reaction:
  1. O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate
  2. O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate
• Enzyme class 3: E.C.3.1.3.27 - phosphatidylglycerophosphatase.
• Reaction: a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate
• Enzyme class 4: E.C.3.1.3.48 - protein-tyrosine-phosphatase.
• Reaction: O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

Proc Natl Acad Sci U S A 108:11860-11865 (2011)

PubMed id: 21730175

Structural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesis.

J.Xiao, J.L.Engel, J.Zhang, M.J.Chen, G.Manning, J.E.Dixon.

ABSTRACT

No abstract given.