PDBsum entry 3rd8

Lyase

PDB id: 3rd8

Contents

Protein chain

457 a.a.

Waters ×278

PDB id:

3rd8

Name:

Lyase

Title:

Crystal structure of fumarate hydratase class ii mycobacterium smegmatis

Structure:

Fumarate hydratase class ii. Chain: a. Engineered: yes

Source:

Mycobacterium smegmatis. Organism_taxid: 246196. Strain: atcc 700084 / mc(2)155. Gene: msmeg_5240. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

2.20Å R-factor: 0.174 R-free: 0.203

Authors:

Seattle Structural Genomics Center For Infectious Disease (Ssgcid)

Key ref:

L.Baugh et al. (2015). Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (edinb), 95, 142-148. PubMed id: 25613812 DOI: 10.1016/j.tube.2014.12.003

Date:

01-Apr-11 Release date: 08-Jun-11

Protein chain

A0R2U8  (A0R2U8_MYCS2) -  Fumarate hydratase class II from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)

Seq: 468 a.a.

Struc: 457 a.a.

Enzyme reactions

• Enzyme class: E.C.4.2.1.2 - fumarate hydratase.
• Pathway: Citric acid cycle
• Reaction: (S)-malate = fumarate + H2O

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

DOI no: 10.1016/j.tube.2014.12.003

Tuberculosis (edinb) 95:142-148 (2015)

PubMed id: 25613812

Increasing the structural coverage of tuberculosis drug targets.

L.Baugh, I.Phan, D.W.Begley, M.C.Clifton, B.Armour, D.M.Dranow, B.M.Taylor, M.M.Muruthi, J.Abendroth, J.W.Fairman, D.Fox, S.H.Dieterich, B.L.Staker, A.S.Gardberg, R.Choi, S.N.Hewitt, A.J.Napuli, J.Myers, L.K.Barrett, Y.Zhang, M.Ferrell, E.Mundt, K.Thompkins, N.Tran, S.Lyons-Abbott, A.Abramov, A.Sekar, D.Serbzhinskiy, D.Lorimer, G.W.Buchko, R.Stacy, L.J.Stewart, T.E.Edwards, W.C.Van Voorhis, P.J.Myler.

ABSTRACT

No abstract given.