PDBsum entry 3qw2

Isomerase

PDB id: 3qw2

Contents

Protein chains

392 a.a.

Ligands

PO4 ×4

NAD ×4

GOL ×2

SO4 ×8

Metals

__K ×3

Waters ×486

PDB id:

3qw2

Name:

Isomerase

Title:

L-myo-inositol 1-phosphate synthase from archaeoglobus mutant n255a

Structure:

Myo-inositol-1-phosphate synthase (ino1). Chain: a, b, c, d. Synonym: mips. Engineered: yes. Mutation: yes

Source:

Archaeoglobus fulgidus. Organism_taxid: 2234. Gene: af1794, af_1794. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.59Å R-factor: 0.189 R-free: 0.267

Authors:

K.Neelon,M.F.Roberts,B.Stec

Key ref:

K.Neelon et al. Atomic crowding drives the catalysis of myo-Inositol phosphate synthase, As deduced from a crystal structu trapped catalytic intermediate. To be published, . PubMed id: 22261071

Date:

26-Feb-11 Release date: 11-Jan-12

Protein chains

O28480  (O28480_ARCFU) -  inositol-3-phosphate synthase from Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)

Seq: 392 a.a.

Struc: 392 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.5.5.1.4 - inositol-3-phosphate synthase.
• Pathway: myo-Inositol Biosynthesis
• Reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate
• Cofactor: NAD(+)

NAD(+) (Bound ligand (Het Group name = NAD) corresponds exactly)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site