PDBsum entry 3py3

Transferase

PDB id: 3py3

Contents

Protein chain

357 a.a.

Waters ×242

PDB id:

3py3

Name:

Transferase

Title:

Crystal structure of phosphorylated p38alpha map kinase

Structure:

Mitogen-activated protein kinase 14. Chain: a. Synonym: map kinase 14, mapk 14, crk1, mitogen-activated protein kinase p38 alpha, map kinase p38 alpha. Engineered: yes

Source:

Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapk14, crk1, csbp1, csbp2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.10Å R-factor: 0.187 R-free: 0.240

Authors:

Y.Y.Zhang,J.W.Wu,Z.X.Wang

Key ref:

Y.Y.Zhang et al. (2011). Mitogen-activated protein kinase (MAPK) phosphatase 3-mediated cross-talk between MAPKs ERK2 and p38alpha. J Biol Chem, 286, 16150-16162. PubMed id: 21454500

Date:

11-Dec-10 Release date: 16-Mar-11

Protein chain

P47811  (MK14_MOUSE) -  Mitogen-activated protein kinase 14 from Mus musculus

Seq: 360 a.a.

Struc: 357 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.2.7.11.24 - mitogen-activated protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

J Biol Chem 286:16150-16162 (2011)

PubMed id: 21454500

Mitogen-activated protein kinase (MAPK) phosphatase 3-mediated cross-talk between MAPKs ERK2 and p38alpha.

Y.Y.Zhang, J.W.Wu, Z.X.Wang.

ABSTRACT

No abstract given.