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PDBsum entry 3omc
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Transcription regulator
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PDB id
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3omc
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Contents |
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* Residue conservation analysis
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PDB id:
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Transcription regulator
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Title:
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Structure of human snd1 extended tudor domain in complex with the symmetrically dimethylated arginine piwil1 peptide r4me2s
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Structure:
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Staphylococcal nuclease domain-containing protein 1. Chain: a, b. Fragment: tudor domain (unp residues 650-910). Synonym: 100 kda coactivator,ebna2 coactivator p100,tudor domain- containing protein 11,p100 co-activator. Engineered: yes. Synthetic peptide. Chain: c, d. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: snd1, tdrd11. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic construct. Organism_taxid: 32630.
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Resolution:
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1.77Å
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R-factor:
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0.180
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R-free:
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0.213
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Authors:
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R.Lam,K.Liu,Y.H.Guo,C.B.Bian,C.Xu,F.Mackenzie,C.Bountra,J.Weigelt, C.H.Arrowsmith,A.M.Edwards,A.Bochkarev,J.Min,Structural Genomics Consortium (Sgc)
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Key ref:
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K.Liu
et al.
(2010).
Structural basis for recognition of arginine methylated Piwi proteins by the extended Tudor domain.
Proc Natl Acad Sci U S A,
107,
18398-18403.
PubMed id:
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Date:
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26-Aug-10
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Release date:
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15-Sep-10
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PROCHECK
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Headers
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References
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Q7KZF4
(SND1_HUMAN) -
Staphylococcal nuclease domain-containing protein 1 from Homo sapiens
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Seq:
Struc:
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910 a.a.
217 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.3.1.31.1
- micrococcal nuclease.
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Reaction:
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Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotide end-products.
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Proc Natl Acad Sci U S A
107:18398-18403
(2010)
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PubMed id:
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Structural basis for recognition of arginine methylated Piwi proteins by the extended Tudor domain.
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K.Liu,
C.Chen,
Y.Guo,
R.Lam,
C.Bian,
C.Xu,
D.Y.Zhao,
J.Jin,
F.MacKenzie,
T.Pawson,
J.Min.
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ABSTRACT
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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C.Xu,
and
J.Min
(2011).
Structure and function of WD40 domain proteins.
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Protein Cell,
2,
202-214.
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PDB codes:
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K.Tripsianes,
T.Madl,
M.Machyna,
D.Fessas,
C.Englbrecht,
U.Fischer,
K.M.Neugebauer,
and
M.Sattler
(2011).
Structural basis for dimethylarginine recognition by the Tudor domains of human SMN and SPF30 proteins.
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Nat Struct Mol Biol,
18,
1414-1420.
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PDB codes:
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M.C.Siomi,
K.Sato,
D.Pezic,
and
A.A.Aravin
(2011).
PIWI-interacting small RNAs: the vanguard of genome defence.
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Nat Rev Mol Cell Biol,
12,
246-258.
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
codes are
shown on the right.
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Links
