PDBsum entry 3og6

Cytokine/cytokine receptor

PDB id: 3og6

Contents

Protein chains

143 a.a. *

200 a.a. *

Ligands

NAG-NAG-BMA

GOL ×4

NAG ×2

Waters ×266

* Residue conservation analysis

PDB id:

3og6

Name:

Cytokine/cytokine receptor

Title:

The crystal structure of human interferon lambda 1 complexed with its high affinity receptor in space group p212121

Structure:

Interleukin-29. Chain: a. Synonym: il-29, interferon lambda-1, ifn-lambda-1, cytokine zcyto21. Engineered: yes. Mutation: yes. Interleukin 28 receptor, alpha (interferon, lambda receptor). Chain: b. Fragment: extracellular domain (unp residue 19-226).

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ifnl1, il29, zcyto21. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227. Gene: hcg_1982865, il28ra, rp11-10n16.1-001.

Resolution:

2.10Å R-factor: 0.185 R-free: 0.228

Authors:

Z.J.Miknis,E.Magracheva,W.Lei,A.Zdanov,S.V.Kotenko,A.Wlodawer

Key ref:

Z.J.Miknis et al. (2010). Crystal structure of human interferon-λ1 in complex with its high-affinity receptor interferon-λR1. J Mol Biol, 404, 650-664. PubMed id: 20934432

Date:

16-Aug-10 Release date: 20-Oct-10

Protein chain

Q8IU54  (IFNL1_HUMAN) -  Interferon lambda-1 from Homo sapiens

Seq: 200 a.a.

Struc: 143 a.a.

Protein chain

Q8IU57  (INLR1_HUMAN) -  Interferon lambda receptor 1 from Homo sapiens

Seq: 520 a.a.

Struc: 200 a.a.

J Mol Biol 404:650-664 (2010)

PubMed id: 20934432

Crystal structure of human interferon-λ1 in complex with its high-affinity receptor interferon-λR1.

Z.J.Miknis, E.Magracheva, W.Li, A.Zdanov, S.V.Kotenko, A.Wlodawer.

ABSTRACT

No abstract given.