 |
PDBsum entry 3of6
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Immune system
|
PDB id
|
|
|
|
3of6
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
Contents |
 |
|
|
|
|
|
|
|
|
|
|
|
240 a.a.
|
|
|
|
|
|
|
|
|
|
|
100 a.a.
|
|
|
|
|
|
|
|
|
|
|
104 a.a.
|
|
|
|
|
|
|
|
|
|
|
* Residue conservation analysis
|
|
|
|
|
|
PDB id:
|
|
|
|
| Name: |
|
Immune system
|
|
|
Title:
|
|
Human pre-t cell receptor crystal structure
|
|
Structure:
|
|
T cell receptor beta chain. Chain: a, b, c. Fragment: ectodomain. Engineered: yes. Mutation: yes. Pre t-cell antigen receptor alpha. Chain: d, e, f. Fragment: ectodomain, unp residues 17-135. Synonym: pre-t alpha chain, pt-alpha, pta, pt-alpha-tcr.
|
|
Source:
|
|
Homo sapiens. Human. Organism_taxid: 9606. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: hifive insect cells.
|
|
Resolution:
|
|
|
2.80Å
|
R-factor:
|
0.179
|
R-free:
|
0.240
|
|
|
Authors:
|
|
S.S.Pang
|
|
Key ref:
|
|
S.S.Pang
et al.
(2010).
The structural basis for autonomous dimerization of the pre-T-cell antigen receptor.
Nature,
467,
844-848.
PubMed id:
|
|
|
Date:
|
|
|
13-Aug-10
|
Release date:
|
20-Oct-10
|
|
|
|
|
|
|
PROCHECK
|
|
|
|
|
|
Headers
|
|
|
|
References
|
|
|
|
|
|
|
|
No UniProt id for this chain
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
| |
|
|
Nature
467:844-848
(2010)
|
|
PubMed id:
|
|
|
|
|
|
| |
|
The structural basis for autonomous dimerization of the pre-T-cell antigen receptor.
|
|
S.S.Pang,
R.Berry,
Z.Chen,
L.Kjer-Nielsen,
M.A.Perugini,
G.F.King,
C.Wang,
S.H.Chew,
N.L.La Gruta,
N.K.Williams,
T.Beddoe,
T.Tiganis,
N.P.Cowieson,
D.I.Godfrey,
A.W.Purcell,
M.C.Wilce,
J.McCluskey,
J.Rossjohn.
|
|
|
|
|
| |
ABSTRACT
|
|
|
|
| |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
 |
 |
|
Literature references that cite this PDB file's key reference
|
|
|
| |
PubMed id
|
|
Reference
|
|
|
|
|
|
N.R.Gascoigne,
and
E.Palmer
(2011).
Signaling in thymic selection.
|
| |
Curr Opin Immunol,
23,
207-212.
|
|
|
|
|
|
|
P.Gosselin,
N.Oulhen,
M.Jam,
J.Ronzca,
P.Cormier,
M.Czjzek,
and
B.Cosson
(2011).
The translational repressor 4E-BP called to order by eIF4E: new structural insights by SAXS.
|
| |
Nucleic Acids Res,
39,
3496-3503.
|
|
|
|
|
|
|
R.Berry,
Z.Chen,
J.McCluskey,
and
J.Rossjohn
(2011).
Insight into the basis of autonomous immunoreceptor activation.
|
| |
Trends Immunol,
32,
165-170.
|
|
|
|
|
|
|
B.Malissen,
and
H.Luche
(2010).
Immunology: Egocentric pre-T-cell receptors.
|
| |
Nature,
467,
793-794.
|
|
|
|
|
|
|
E.Ishikawa,
Y.Miyake,
H.Hara,
T.Saito,
and
S.Yamasaki
(2010).
Germ-line elimination of electric charge on pre-T-cell receptor (TCR) impairs autonomous signaling for beta-selection and TCR repertoire formation.
|
| |
Proc Natl Acad Sci U S A,
107,
19979-19984.
|
|
|
|
|
|
The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
|
|
| |
Links
