PDBsum entry 3oap

Transcription

PDB id: 3oap

Contents

Protein chains

214 a.a. *

11 a.a. *

Ligands

9CR

Waters ×144

* Residue conservation analysis

PDB id:

3oap

Name:

Transcription

Title:

Crystal structure of human retinoid x receptor alpha-ligand binding domain complex with 9-cis retinoic acid and the coactivator peptide grip-1

Structure:

Retinoic acid receptor rxr-alpha. Chain: a. Fragment: hrxralpha-lbd, unp residues 228-458. Synonym: retinoid x receptor alpha, nuclear receptor subfamily 2 group b member 1. Engineered: yes. Nuclear receptor coactivator 2. Chain: b. Fragment: grip-1, unp residues 686-696.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: rxra, nr2b1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606

Resolution:

2.05Å R-factor: 0.204 R-free: 0.244

Authors:

G.Xia,C.D.Smith,D.D.Muccio

Key ref:

G.Xia et al. (2011). Structure, energetics, and dynamics of binding coactivator peptide to the human retinoid X receptor α ligand binding domain complex with 9-cis-retinoic acid. Biochemistry, 50, 93. PubMed id: 21049972

Date:

05-Aug-10 Release date: 17-Nov-10

Protein chain

P19793  (RXRA_HUMAN) -  Retinoic acid receptor RXR-alpha from Homo sapiens

Seq: 462 a.a.

Struc: 214 a.a.

Protein chain

Q15596  (NCOA2_HUMAN) -  Nuclear receptor coactivator 2 from Homo sapiens

Seq: 1464 a.a.

Struc: 11 a.a.

Enzyme reactions

• Enzyme class: Chains A, B: E.C.?

Biochemistry 50:93 (2011)

PubMed id: 21049972

Structure, energetics, and dynamics of binding coactivator peptide to the human retinoid X receptor α ligand binding domain complex with 9-cis-retinoic acid.

G.Xia, L.J.Boerma, B.D.Cox, C.Qiu, S.Kang, C.D.Smith, M.B.Renfrow, D.D.Muccio.

ABSTRACT

No abstract given.