PDBsum entry 3o2x

Hydrolase

PDB id: 3o2x

Contents

Protein chains

164 a.a.

Ligands

3O2 ×4

SO4 ×9

EPE ×2

Metals

_ZN ×8

_CA ×8

Waters ×682

PDB id:

3o2x

Name:

Hydrolase

Title:

Mmp-13 in complex with selective tetrazole core inhibitor

Structure:

Collagenase 3. Chain: a, b, c, d. Fragment: catalytic domain. Synonym: matrix metalloproteinase-13, mmp-13. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp13. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.90Å R-factor: 0.178 R-free: 0.210

Authors:

J.R.Kiefer,T.E.Barta,D.P.Becker,K.J.Mathis,J.Williams

Key ref:

T.E.Barta et al. Mmp-13 in complex with selective tetrazole core inhib. To be published, .

Date:

22-Jul-10 Release date: 10-Aug-11

Protein chains

P45452  (MMP13_HUMAN) -  Collagenase 3 from Homo sapiens

Seq: 471 a.a.

Struc: 164 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.3.4.24.- - ?????