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PDBsum entry 3npy
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protein metals Protein-protein interface(s) links
Oxidoreductase PDB id
3npy

 

 

 

 

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Contents
Protein chains
281 a.a. *
Metals
_CL ×6
_CU ×4
_ZN ×8
Waters ×172
* Residue conservation analysis
PDB id:
3npy
Name: Oxidoreductase
Title: Crystal structure of tyrosinase from bacillus megaterium soaked in cuso4
Structure: Tyrosinase. Chain: a, b. Engineered: yes
Source: Bacillus megaterium. Organism_taxid: 1404. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.19Å     R-factor:   0.250     R-free:   0.275
Authors: M.Sendovski,M.Kanteev,N.Adir,A.Fishman
Key ref: M.Sendovski et al. (2011). First structures of an active bacterial tyrosinase reveal copper plasticity. J Mol Biol, 405, 227-237. PubMed id: 21040728
Date:
29-Jun-10     Release date:   17-Nov-10    
PROCHECK
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 Headers
 References

Protein chains
B2ZB02  (B2ZB02_PRIMG) -  Tyrosinase from Priestia megaterium
Seq:
Struc: 		297 a.a.
281 a.a.
Key:    Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.1.14.18.1  - tyrosinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway: 		Melanin Biosynthesis
      Reaction:
1. L-tyrosine + O2 = L-dopaquinone + H2O
2. 2 L-dopa + O2 = 2 L-dopaquinone + 2 H2O
L-tyrosine
 + O2
 = L-dopaquinone
 + H2O
2 × L-dopa
 + O2
 = 2 × L-dopaquinone
 + 2 × H2O
      Cofactor: Cu cation
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 
    reference    
 
 
J Mol Biol 405:227-237 (2011)
PubMed id: 21040728  
 
 
First structures of an active bacterial tyrosinase reveal copper plasticity.
M.Sendovski, M.Kanteev, V.S.Ben-Yosef, N.Adir, A.Fishman.
 
  ABSTRACT  
 
No abstract given.

 

 

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