PDBsum entry 3nmd

Transferase

PDB id

3nmd

Loading ...

Contents

			Protein chains

					53 a.a.


					47 a.a.


					53 a.a.


					50 a.a.

			Ligands

					HEZ ×7


					GOL

			Waters ×100

PDB id:

3nmd

Links

Name:

Transferase

Title:

Crystal structure of the leucine zipper domain of cgmp dependent protein kinase i beta

Structure:

Cgmp dependent protein kinase. Chain: a, b, c, d, e. Fragment: dimerization docking domain, unp residues 4-55. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: prkg1. Expressed in: escherichia coli. Expression_system_taxid: 511693.

Resolution:

2.27Å

R-factor:

0.197

R-free:

0.248

Authors:

C.Kim,D.E.Casteel,E.V.Smith-Nguyen,B.Sankaran,Berkeley Structural Genomics Center (Bsgc)

Key ref:

D.E.Casteel et al. (2010). A crystal structure of the cyclic GMP-dependent protein kinase I{beta} dimerization/docking domain reveals molecular details of isoform-specific anchoring. J Biol Chem, 285, 32684-32688. PubMed id: 20826808

Date:

22-Jun-10

Release date:

08-Sep-10

PROCHECK

	Headers

	References

Protein chain

Q13976 (KGP1_HUMAN) - cGMP-dependent protein kinase 1 from Homo sapiens

Seq: Struc:

Seq: Struc:					671 a.a. 53 a.a.*

Protein chain

Q13976 (KGP1_HUMAN) - cGMP-dependent protein kinase 1 from Homo sapiens

Seq: Struc:

Seq: Struc:					671 a.a. 47 a.a.*

Protein chain

Q13976 (KGP1_HUMAN) - cGMP-dependent protein kinase 1 from Homo sapiens

Seq: Struc:

Seq: Struc:					671 a.a. 53 a.a.*

Protein chains

Q13976 (KGP1_HUMAN) - cGMP-dependent protein kinase 1 from Homo sapiens

Seq: Struc:

Seq: Struc:					671 a.a. 50 a.a.*

Key:

PfamA domain

Secondary structure

CATH domain

* PDB and UniProt seqs differ at 127 residue positions (black crosses)



		Enzyme reactions

Enzyme class:

Chains A, B, C, D, E: E.C.2.7.11.12 - cGMP-dependent protein kinase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

1.	L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
2.	L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

L-seryl-[protein]	+	ATP	=	O-phospho-L-seryl-[protein]	+	ADP	+	H(+)

L-threonyl-[protein]	+	ATP	=	O-phospho-L-threonyl-[protein]	+	ADP	+	H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

	J Biol Chem 285:32684-32688 (2010)
PubMed id: 20826808

A crystal structure of the cyclic GMP-dependent protein kinase I{beta} dimerization/docking domain reveals molecular details of isoform-specific anchoring.
D.E.Casteel, E.V.Smith-Nguyen, B.Sankaran, S.H.Roh, R.B.Pilz, C.Kim.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

21517872

J.C.Harris, M.Hrmova, S.Lopato, and P.Langridge (2011).
Modulation of plant growth by HD-Zip class I and II transcription factors in response to environmental stimuli.

New Phytol, 190, 823-837.

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.