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PDBsum entry 3n6c
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Oxidoreductase/oxidoreductase inhibitor
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PDB id
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3n6c
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Contents |
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* Residue conservation analysis
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PDB id:
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| Name: |
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Oxidoreductase/oxidoreductase inhibitor
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Title:
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Structure of endothelial nitric oxide synthase h373s single mutant heme domain complexed with 4-(2-(6-(2-(6-amino-4-methylpyridin-2-yl) ethyl)pyridin-2-yl)ethyl)-6-methylpyridin-2-amine
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Structure:
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Nitric oxide synthase. Chain: a, b. Synonym: endothelial nos, enos, ec-nos, nos type iii, nosiii, constitutive nos, cnos. Engineered: yes
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Source:
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Bos taurus. Cow. Organism_taxid: 9913. Gene: nos3. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Resolution:
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3.06Å
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R-factor:
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0.238
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R-free:
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0.332
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Authors:
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S.L.Delker,H.Li,T.L.Poulos
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Key ref:
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S.L.Delker
et al.
(2010).
Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Biochemistry,
49,
10803-10810.
PubMed id:
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Date:
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25-May-10
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Release date:
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09-Feb-11
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PROCHECK
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Headers
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References
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P29476
(NOS1_RAT) -
Nitric oxide synthase 1 from Rattus norvegicus
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Seq:
Struc:
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1429 a.a.
404 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 126 residue positions (black
crosses)
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Enzyme class:
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E.C.1.14.13.39
- nitric-oxide synthase (NADPH).
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Reaction:
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2 L-arginine + 3 NADPH + 4 O2 + H+ = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O
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2
×
L-arginine
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+
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3
×
NADPH
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+
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4
×
O2
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+
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H(+)
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=
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2
×
L-citrulline
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+
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2
×
nitric oxide
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+
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3
×
NADP(+)
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+
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4
×
H2O
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Biochemistry
49:10803-10810
(2010)
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PubMed id:
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Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
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S.L.Delker,
F.Xue,
H.Li,
J.Jamal,
R.B.Silverman,
T.L.Poulos.
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ABSTRACT
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Links
