PDBsum entry 3mw3

Cell adhesion

PDB id

3mw3

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Contents

			Protein chain

					189 a.a. *

			Ligands

					NAG-NAG-BMA

			Metals

					_CA ×2

			Waters ×135

* Residue conservation analysis

PDB id:

3mw3

Links

Name:

Cell adhesion

Title:

Crystal structure of beta-neurexin 2 with the splice insert 4

Structure:

Neurexin-2-beta. Chain: a. Fragment: unp residues 1140 to 1343. Synonym: nrxn2. Engineered: yes

Source:

Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: nrxn2. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293

Resolution:

2.33Å

R-factor:

0.194

R-free:

0.252

Authors:

X.Jin,L.Shapiro

Key ref:

J.Koehnke et al. (2010). Splice form dependence of beta-neurexin/neuroligin binding interactions. Neuron, 67, 61-74. PubMed id: 20624592

Date:

05-May-10

Release date:

28-Jul-10

PROCHECK

	Headers

	References

Protein chain

Q63376 (NRX2B_RAT) - Neurexin-2-beta from Rattus norvegicus

Seq: Struc:

Seq: Struc:					662 a.a. 189 a.a.*

Key:

PfamA domain

Secondary structure

CATH domain

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

	Neuron 67:61-74 (2010)
PubMed id: 20624592

Splice form dependence of beta-neurexin/neuroligin binding interactions.
J.Koehnke, P.S.Katsamba, G.Ahlsen, F.Bahna, J.Vendome, B.Honig, L.Shapiro, X.Jin.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

22902367

O.J.Harrison, J.Vendome, J.Brasch, X.Jin, S.Hong, P.S.Katsamba, G.Ahlsen, R.B.Troyanovsky, S.M.Troyanovsky, B.Honig, and L.Shapiro (2012).
Nectin ectodomain structures reveal a canonical adhesive interface.

Nat Struct Mol Biol, 19, 906-915.

PDB codes:

4fmf 4fmk 4fn0 4fom 4fqp 4frw 4fs0

21155806

G.J.Wright, and P.Washbourne (2011).
Neurexins, neuroligins and LRRTMs: synaptic adhesion getting fishy.

J Neurochem, 117, 765-778.

21342763

M.Yuzaki (2011).
Cbln1 and its family proteins in synapse formation and maintenance.

Curr Opin Neurobiol, 21, 215-220.

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB codes are shown on the right.