PDBsum entry 3ms2

Transferase/transferase inhibitor

PDB id: 3ms2

Contents

Protein chain

811 a.a. *

Ligands

18S ×2

Waters ×262

* Residue conservation analysis

PDB id:

3ms2

Name:

Transferase/transferase inhibitor

Title:

Glycogen phosphorylase complexed with 4-methylbenzaldehyde-4-(beta-d- glucopyranosyl) thiosemicarbazone

Structure:

Glycogen phosphorylase, muscle form. Chain: a. Synonym: myophosphorylase. Ec: 2.4.1.1

Source:

Oryctolagus cuniculus. European rabbit,japanese white rabbit,domestic rabbit,rabbits. Organism_taxid: 9986. Other_details: muscle

Resolution:

2.10Å R-factor: 0.185 R-free: 0.223

Authors:

K.-M.Alexacou

Key ref:

K.M.Alexacou et al. (2010). The binding of β-d-glucopyranosyl-thiosemicarbazone derivatives to glycogen phosphorylase: A new class of inhibitors. Bioorg Med Chem Lett, 18, 7911-7922. PubMed id: 20947361

Date:

29-Apr-10 Release date: 05-Jan-11

Protein chain

P00489  (PYGM_RABIT) -  Glycogen phosphorylase, muscle form from Oryctolagus cuniculus

Seq: 843 a.a.

Struc: 811 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.2.4.1.1 - glycogen phosphorylase.
• Pathway: Glycogen
• Reaction: [(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

Bioorg Med Chem Lett 18:7911-7922 (2010)

PubMed id: 20947361

The binding of β-d-glucopyranosyl-thiosemicarbazone derivatives to glycogen phosphorylase: A new class of inhibitors.

K.M.Alexacou, A.C.Tenchiu Deleanu, E.D.Chrysina, M.D.Charavgi, I.D.Kostas, S.E.Zographos, N.G.Oikonomakos, D.D.Leonidas.

ABSTRACT

No abstract given.