PDBsum entry 3mpa

Transferase

PDB id: 3mpa

Contents

Protein chain

331 a.a. *

Ligands

SB2

BOG

Waters ×146

* Residue conservation analysis

PDB id:

3mpa

Name:

Transferase

Title:

Conformational plasticity of p38 map kinase dfg motif mutants in response to inhibitor binding

Structure:

Mitogen-activated protein kinase 14. Chain: a. Synonym: map kinase 14, mapk 14, mitogen-activated protein kinase p38 alpha, map kinase p38 alpha, cytokine suppressive anti-inflammatory drug-binding protein, csaid-binding protein, csbp, max-interacting protein 2, map kinase mxi2, sapk2a. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2

Resolution:

2.10Å R-factor: 0.235 R-free: 0.289

Authors:

H.V.Namboodiri,M.Karpusas,M.Bukhtiyarova,E.B.Springman

Key ref:

H.V.Namboodiri et al. Conformational plasticity of p38 map kinase dfg motif mutants in response to inhibitor binding. To be published, .

Date:

26-Apr-10 Release date: 15-Sep-10

Protein chain

Q16539  (MK14_HUMAN) -  Mitogen-activated protein kinase 14 from Homo sapiens

Seq: 360 a.a.

Struc: 331 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.2.7.11.24 - mitogen-activated protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site