spacer
spacer

PDBsum entry 3mb4

Go to PDB code: 
protein ligands metals Protein-protein interface(s) links
Transcription PDB id
3mb4

 

 

 

 

Loading ...

 
JSmol PyMol  
Contents
Protein chains
115 a.a. *
Ligands
EDO ×5
MB3 ×2
Metals
_CL ×4
Waters ×209
* Residue conservation analysis
PDB id:
3mb4
Name: Transcription
Title: Crystal structure of the fifth bromodomain of human poly-bromodomain containing protein 1 (pb1) with nmp
Structure: Protein polybromo-1. Chain: a, b. Fragment: unp residues 645-766. Synonym: hpb1, polybromo-1d, brg1-associated factor 180, baf180. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: baf180, pb1, pbrm1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Resolution:
1.66Å     R-factor:   0.198     R-free:   0.219
Authors: P.Filippakopoulos,S.Picaud,T.Keates,E.Ugochukwu,F.Von Delft, C.H.Arrowsmith,A.M.Edwards,J.Weigelt,C.Bountra,S.Knapp,Structural Genomics Consortium (Sgc)
Key ref: P.Filippakopoulos et al. (2012). Histone recognition and large-scale structural analysis of the human bromodomain family. Cell, 149, 214-231. PubMed id: 22464331
Date:
25-Mar-10     Release date:   14-Apr-10    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q86U86  (PB1_HUMAN) -  Protein polybromo-1 from Homo sapiens
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
1689 a.a.
115 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.?
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

 

 
Cell 149:214-231 (2012)
PubMed id: 22464331  
 
 
Histone recognition and large-scale structural analysis of the human bromodomain family.
P.Filippakopoulos, S.Picaud, M.Mangos, T.Keates, J.P.Lambert, D.Barsyte-Lovejoy, I.Felletar, R.Volkmer, S.Müller, T.Pawson, A.C.Gingras, C.H.Arrowsmith, S.Knapp.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
23211769 C.A.Musselman, M.E.Lalonde, J.Côté, and T.G.Kutateladze (2012).
Perceiving the epigenetic landscape through histone readers.
  Nat Struct Mol Biol, 19, 1218-1227.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.

 

spacer

spacer