PDBsum entry 3m0c

Protein binding

PDB id: 3m0c

Contents

Protein chains

92 a.a.

486 a.a.

430 a.a.

Metals

_CA ×3

PDB id:

3m0c

Name:

Protein binding

Title:

The x-ray crystal structure of pcsk9 in complex with the ldl receptor

Structure:

Proprotein convertase subtilisin/kexin type 9. Chain: a. Fragment: pcsk9. Synonym: proprotein convertase 9, pc9, subtilisin/kexin-like protease pc9, neural apoptosis-regulated convertase 1, narc-1. Engineered: yes. Proprotein convertase subtilisin/kexin type 9. Chain: b. Fragment: pcsk9.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: narc1, pcsk9, psec0052. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293. Gene: ldlr. Expression_system_cell_line: hek293

Resolution:

7.01Å R-factor: 0.342 R-free: 0.362

Authors:

G.Spraggon,E.N.Hampton

Key ref:

J.Li et al. The X-Ray crystal structure of pcsk9 in complex with receptor. To be published, .

Date:

02-Mar-10 Release date: 16-Mar-11

Protein chain

Q8NBP7  (PCSK9_HUMAN) -  Proprotein convertase subtilisin/kexin type 9 from Homo sapiens

Seq: 692 a.a.

Struc: 92 a.a.

Protein chain

Q8NBP7  (PCSK9_HUMAN) -  Proprotein convertase subtilisin/kexin type 9 from Homo sapiens

Seq: 692 a.a.

Struc: 486 a.a.*

Protein chain

P01130  (LDLR_HUMAN) -  Low-density lipoprotein receptor from Homo sapiens

Seq: 860 a.a.

Struc: 430 a.a.

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chains A, B: E.C.3.4.21.- - ?????