PDBsum entry 3lxu

Hydrolase

PDB id

3lxu

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Contents

			Protein chain

					1217 a.a. *

* Residue conservation analysis

PDB id:

3lxu

Links

Name:

Hydrolase

Title:

Crystal structure of tripeptidyl peptidase 2 (tpp ii)

Structure:

Tripeptidyl-peptidase 2. Chain: x. Fragment: residus 463-770. Synonym: tripeptidyl-peptidase ii, dtpp ii, tpp-ii, tripeptidyl aminopeptidase. Engineered: yes

Source:

Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: cg3991, tpp ii, tppii. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

3.14Å

R-factor:

0.241

R-free:

0.293

Authors:

C.K.Chuang

Key ref:

C.K.Chuang et al. (2010). Hybrid molecular structure of the giant protease tripeptidyl peptidase II. Nat Struct Biol, 17, 990-996. PubMed id: 20676100

Date:

25-Feb-10

Release date:

11-Aug-10

PROCHECK

	Headers

	References

Protein chain

Q9V6K1 (TPP2_DROME) - Tripeptidyl-peptidase 2 from Drosophila melanogaster

Seq: Struc:

Seq: Struc:

Seq: Struc:					1441 a.a. 1217 a.a.

Key:

PfamA domain

Secondary structure

CATH domain



		Enzyme reactions

Enzyme class:

E.C.3.4.14.10 - tripeptidyl-peptidase Ii.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

Release of an N-terminal tripeptide from a polypeptide.

	Nat Struct Biol 17:990-996 (2010)
PubMed id: 20676100

Hybrid molecular structure of the giant protease tripeptidyl peptidase II.
C.K.Chuang, B.Rockel, G.Seyit, P.J.Walian, A.M.Schönegge, J.Peters, P.H.Zwart, W.Baumeister, B.K.Jap.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

20935055

C.L.Lawson, M.L.Baker, C.Best, C.Bi, M.Dougherty, P.Feng, G.van Ginkel, B.Devkota, I.Lagerstedt, S.J.Ludtke, R.H.Newman, T.J.Oldfield, I.Rees, G.Sahni, R.Sala, S.Velankar, J.Warren, J.D.Westbrook, K.Henrick, G.J.Kleywegt, H.M.Berman, and W.Chiu (2011).
EMDataBank.org: unified data resource for CryoEM.

Nucleic Acids Res, 39, D456-D464.

21390545

P.van Endert (2011).
Post-proteasomal and proteasome-independent generation of MHC class I ligands.

Cell Mol Life Sci, 68, 1553-1567.

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.