PDBsum entry 3lcs

Transferase

PDB id

3lcs

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Contents

			Protein chain

					304 a.a. *

			Ligands

					STU


					GOL ×2

			Waters ×119

* Residue conservation analysis

PDB id:

3lcs

Links

Name:

Transferase

Title:

Crystal structure of the anaplastic lymphoma kinase catalytic domain

Structure:

Alk tyrosine kinase receptor. Chain: a. Fragment: catalytic domain residues 1072-1410. Synonym: anaplastic lymphoma kinase. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: alk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Resolution:

1.95Å

R-factor:

0.196

R-free:

0.229

Authors:

C.C.Lee

Key ref:

C.C.Lee et al. (2010). Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain. Biochem J, 430, 425-437. PubMed id: 20632993

Date:

11-Jan-10

Release date:

04-Aug-10

PROCHECK

	Headers

	References

Protein chain

Q9UM73 (ALK_HUMAN) - ALK tyrosine kinase receptor from Homo sapiens

Seq: Struc:

Seq: Struc:

Seq: Struc:

Seq: Struc:					1620 a.a. 304 a.a.*

Key:

PfamA domain

Secondary structure

CATH domain

* PDB and UniProt seqs differ at 1 residue position (black cross)



		Enzyme reactions

Enzyme class:

E.C.2.7.10.1 - receptor protein-tyrosine kinase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

L-tyrosyl-[protein]	+	ATP	=	O-phospho-L-tyrosyl-[protein]	+	ADP	+	H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

	Biochem J 430:425-437 (2010)
PubMed id: 20632993

Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain.
C.C.Lee, Y.Jia, N.Li, X.Sun, K.Ng, E.Ambing, M.Y.Gao, S.Hua, C.Chen, S.Kim, P.Y.Michellys, S.A.Lesley, J.L.Harris, G.Spraggon.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

22585002

E.L.Carpenter, and Y.P.Mossé (2012).
Targeting ALK in neuroblastoma--preclinical and clinical advancements.

Nat Rev Clin Oncol, 9, 391-399.

21383740

A.Wellstein, and J.A.Toretsky (2011).
Hunting ALK to feed targeted cancer therapy.

Nat Med, 17, 290-291.

21515061

M.Okamoto, H.Kojima, N.Saito, T.Okabe, Y.Masuda, T.Furuya, and T.Nagano (2011).
Virtual screening and further development of novel ALK inhibitors.

Bioorg Med Chem, 19, 3086-3095.

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.