 |
PDBsum entry 3jwt
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Oxidoreductase
|
PDB id
|
|
|
|
3jwt
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
Contents |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
* Residue conservation analysis
|
|
|
|
|
|
PDB id:
|
|
|
|
| Name: |
|
Oxidoreductase
|
|
|
Title:
|
|
Structure of rat neuronal nitric oxide synthase r349a mutant heme domain in complex with n1-{(3'r,4'r)-4'-[(6"-amino-4"-methylpyridin- 2"-yl)methyl]pyrrolidin-3'-yl}-n2-(3'-fluorophenethyl)ethane-1,2- diamine
|
|
Structure:
|
|
Nitric oxide synthase, brain. Chain: a, b. Fragment: residues 297-718. Synonym: bnos, nos type i, neuronal nos, n-nos, nnos, constitutive nos, nc-nos. Engineered: yes. Mutation: yes
|
|
Source:
|
|
Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: nos1, bnos. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
Resolution:
|
|
|
2.01Å
|
R-factor:
|
0.189
|
R-free:
|
0.225
|
|
|
Authors:
|
|
S.L.Delker,H.Li,T.L.Poulos
|
|
Date:
|
|
|
18-Sep-09
|
Release date:
|
05-May-10
|
|
|
|
|
|
|
PROCHECK
|
|
|
|
|
|
Headers
|
|
|
|
References
|
|
|
|
|
|
|
|
P29476
(NOS1_RAT) -
Nitric oxide synthase 1 from Rattus norvegicus
|
|
|
|
Seq:
Struc:
|
|
|
|
1429 a.a.
407 a.a.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Key: |
 |
PfamA domain |
|
|
 |
Secondary structure |
|
 |
CATH domain |
|
|
|
|
|
|
|
|
|
|
|
|
|
Enzyme class:
|
|
E.C.1.14.13.39
- nitric-oxide synthase (NADPH).
|
|
|
|
|
|
|
Reaction:
|
|
2 L-arginine + 3 NADPH + 4 O2 + H+ = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O
|
|
|
|
|
|
2
×
L-arginine
|
+
|
3
×
NADPH
|
+
|
4
×
O2
|
+
|
H(+)
|
=
|
2
×
L-citrulline
|
+
|
2
×
nitric oxide
|
+
|
3
×
NADP(+)
|
+
|
4
×
H2O
|
|
|
|
|
|
|
|
|
|
|
|
|
Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
|
|
|
|
Links
