PDBsum entry 3ipe

Hormone

PDB id

3ipe

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Contents

			Protein chain

					115 a.a. *

			Ligands

					JZE

			Waters ×138

* Residue conservation analysis

PDB id:

3ipe

Links

Name:

Hormone

Title:

Human transthyretin (ttr) complexed with a palindromic bivalent amyloid inhibitor (7 carbon linker).

Structure:

Transthyretin. Chain: a, b. Fragment: unp residues 21-147. Synonym: prealbumin, tbpa, ttr, attr

Source:

Homo sapiens. Human. Organism_taxid: 9606

Resolution:

1.40Å

R-factor:

0.176

R-free:

0.196

Authors:

S.E.Kolstoe,S.P.Wood,M.B.Pepys

Key ref:

S.E.Kolstoe et al. (2010). Trapping of palindromic ligands within native transthyretin prevents amyloid formation. Proc Natl Acad Sci U S A, 107, 20483-20488. PubMed id: 21059958

Date:

17-Aug-09

Release date:

17-Nov-10

PROCHECK

	Headers

	References

Protein chains

P02766 (TTHY_HUMAN) - Transthyretin from Homo sapiens

Seq: Struc:					147 a.a. 115 a.a.

Key:

PfamA domain

Secondary structure

CATH domain

	Proc Natl Acad Sci U S A 107:20483-20488 (2010)
PubMed id: 21059958

Trapping of palindromic ligands within native transthyretin prevents amyloid formation.
S.E.Kolstoe, P.P.Mangione, V.Bellotti, G.W.Taylor, G.A.Tennent, S.Deroo, A.J.Morrison, A.J.Cobb, A.Coyne, M.G.McCammon, T.D.Warner, J.Mitchell, R.Gill, M.D.Smith, S.V.Ley, C.V.Robinson, S.P.Wood, M.B.Pepys.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

21267559

R.H.Falk, and S.Dorbala (2011).
Pursuing an underdiagnosed disease: a simple imaging test for increasing suspicion of cardiac amyloidosis.

Eur J Nucl Med Mol Imaging, 38, 467-469.

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.