PDBsum entry 3h5h

Lyase

PDB id: 3h5h

Contents

Protein chains

166 a.a. *

Waters ×39

* Residue conservation analysis

PDB id:

3h5h

Name:

Lyase

Title:

Leud_1-186 small subunit of isopropylmalate isomerase (rv2987c) from mycobacterium tuberculosis

Structure:

3-isopropylmalate dehydratase small subunit. Chain: a, b. Fragment: leud, residues 1-186. Synonym: isopropylmalate isomerase small subunit, alpha-ipm isomerase, ipmi. Engineered: yes

Source:

Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: rv2987c. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.50Å R-factor: 0.228 R-free: 0.269

Authors:

K.Manikandan,A.Geerlof,M.S.Weiss

Key ref:

K.Manikandan et al. (2011). Structural studies on the enzyme complex isopropylmalate isomerase (LeuCD) from Mycobacterium tuberculosis. Proteins, 79, 35-49. PubMed id: 20938981

Date:

22-Apr-09 Release date: 07-Apr-10

Protein chains

P9WK95  (LEUD_MYCTU) -  3-isopropylmalate dehydratase small subunit from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

Seq: 198 a.a.

Struc: 166 a.a.

Enzyme reactions

• Enzyme class: E.C.4.2.1.33 - 3-isopropylmalate dehydratase.
• Pathway: Leucine Biosynthesis
• Reaction: (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate
• Cofactor: Iron-sulfur

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

Proteins 79:35-49 (2011)

PubMed id: 20938981

Structural studies on the enzyme complex isopropylmalate isomerase (LeuCD) from Mycobacterium tuberculosis.

K.Manikandan, A.Geerlof, A.V.Zozulya, D.I.Svergun, M.S.Weiss.

ABSTRACT

No abstract given.