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PDBsum entry 3gwc
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Contents |
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* Residue conservation analysis
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PDB id:
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Transferase
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Title:
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Crystal structure of mycobacterium tuberculosis thymidylate synthase x bound to fdump and fad
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Structure:
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Thymidylate synthase thyx. Chain: a, b, c, d, e, f, g, h. Synonym: ts, tsase. Engineered: yes
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Source:
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Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: thyx, rv2754c, mt2824, mtv002.19c. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Resolution:
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1.90Å
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R-factor:
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0.189
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R-free:
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0.229
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Authors:
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Seattle Structural Genomics Center For Infectious Disease (Ssgcid)
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Key ref:
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L.Baugh
et al.
(2015).
Increasing the structural coverage of tuberculosis drug targets.
Tuberculosis (edinb),
95,
142-148.
PubMed id:
DOI:
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Date:
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31-Mar-09
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Release date:
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28-Apr-09
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PROCHECK
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Headers
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References
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P9WG57
(THYX_MYCTU) -
Flavin-dependent thymidylate synthase from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
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Seq:
Struc:
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250 a.a.
246 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.2.1.1.148
- thymidylate synthase (FAD).
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Reaction:
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dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADPH + H+ = dTMP + (6S)-5,6,7,8-tetrahydrofolate + NADP+
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dUMP
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+
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(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate
Bound ligand (Het Group name = )
matches with 95.24% similarity
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+
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NADPH
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+
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H(+)
Bound ligand (Het Group name = )
matches with 71.19% similarity
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=
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dTMP
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(6S)-5,6,7,8-tetrahydrofolate
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+
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NADP(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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DOI no:
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Tuberculosis (edinb)
95:142-148
(2015)
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PubMed id:
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Increasing the structural coverage of tuberculosis drug targets.
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L.Baugh,
I.Phan,
D.W.Begley,
M.C.Clifton,
B.Armour,
D.M.Dranow,
B.M.Taylor,
M.M.Muruthi,
J.Abendroth,
J.W.Fairman,
D.Fox,
S.H.Dieterich,
B.L.Staker,
A.S.Gardberg,
R.Choi,
S.N.Hewitt,
A.J.Napuli,
J.Myers,
L.K.Barrett,
Y.Zhang,
M.Ferrell,
E.Mundt,
K.Thompkins,
N.Tran,
S.Lyons-Abbott,
A.Abramov,
A.Sekar,
D.Serbzhinskiy,
D.Lorimer,
G.W.Buchko,
R.Stacy,
L.J.Stewart,
T.E.Edwards,
W.C.Van Voorhis,
P.J.Myler.
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ABSTRACT
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Links
