PDBsum entry 3f9m

Transferase

PDB id: 3f9m

Contents

Protein chain

451 a.a. *

Ligands

GLC

MRK

Waters ×440

* Residue conservation analysis

PDB id:

3f9m

Name:

Transferase

Title:

Human pancreatic glucokinase in complex with glucose and activator showing a mobile flap

Structure:

Glucokinase. Chain: a. Fragment: unp residues 12-465. Synonym: hexokinase type iv, hk iv, hexokinase-4, hk4, hexokinase-d. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.50Å R-factor: 0.191 R-free: 0.222

Authors:

P.Petit,L.Gluais,A.Lagarde,L.Vuillard,J.A.Boutin,G.Ferry

Key ref:

P.Petit et al. (2011). The active conformation of human glucokinase is not altered by allosteric activators. Acta Crystallogr D Biol Crystallogr, 67, 929-935. PubMed id: 22101819

Date:

14-Nov-08 Release date: 02-Dec-08

Protein chain

P35557  (HXK4_HUMAN) -  Hexokinase-4 from Homo sapiens

Seq: 465 a.a.

Struc: 451 a.a.*

* PDB and UniProt seqs differ at 8 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.1.1 - hexokinase.
• Reaction: a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H⁺

D-hexose + ATP (Bound ligand (Het Group name = GLC) corresponds exactly) = D-hexose 6-phosphate + ADP + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

Acta Crystallogr D Biol Crystallogr 67:929-935 (2011)

PubMed id: 22101819

The active conformation of human glucokinase is not altered by allosteric activators.

P.Petit, M.Antoine, G.Ferry, J.A.Boutin, A.Lagarde, L.Gluais, R.Vincentelli, L.Vuillard.

ABSTRACT

No abstract given.