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PDBsum entry 3f0f
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* Residue conservation analysis
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PDB id:
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Lyase
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Title:
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Co-crystal structure of 2c-methyl-d-erythritol 2,4-cyclodiphosphate synthase from burkholderia pseudomallei with hydrolyzed cdp
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Structure:
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2-c-methyl-d-erythritol 2,4-cyclodiphosphate synthase. Chain: a, b, c. Synonym: mecps, mecdp-synthase. Engineered: yes
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Source:
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Burkholderia pseudomallei. Pseudomonas pseudomallei. Organism_taxid: 28450. Strain: 1710b. Gene: ispf, mecs, bpsl2098. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Resolution:
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2.09Å
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R-factor:
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0.200
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R-free:
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0.246
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Authors:
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Seattle Structural Genomics Center For Infectious Disease (Ssgcid)
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Key ref:
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L.Baugh
et al.
(2013).
Combining functional and structural genomics to sample the essential Burkholderia structome.
Plos One,
8,
e53851.
PubMed id:
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Date:
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24-Oct-08
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Release date:
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04-Nov-08
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PROCHECK
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Headers
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References
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Q3JRA0
(ISPF_BURP1) -
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase from Burkholderia pseudomallei (strain 1710b)
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Seq:
Struc:
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162 a.a.
159 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.4.6.1.12
- 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase.
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Reaction:
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4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4- cyclic diphosphate + CMP
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4-CDP-2-C-methyl-D-erythritol 2-phosphate
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=
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2-C-methyl-D-erythritol 2,4- cyclic diphosphate
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+
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CMP
Bound ligand (Het Group name = )
corresponds exactly
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Cofactor:
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Mn(2+) or Mg(2+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Plos One
8:e53851
(2013)
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PubMed id:
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Combining functional and structural genomics to sample the essential Burkholderia structome.
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L.Baugh,
L.A.Gallagher,
R.Patrapuvich,
M.C.Clifton,
A.S.Gardberg,
T.E.Edwards,
B.Armour,
D.W.Begley,
S.H.Dieterich,
D.M.Dranow,
J.Abendroth,
J.W.Fairman,
D.Fox,
B.L.Staker,
I.Phan,
A.Gillespie,
R.Choi,
S.Nakazawa-Hewitt,
M.T.Nguyen,
A.Napuli,
L.Barrett,
G.W.Buchko,
R.Stacy,
P.J.Myler,
L.J.Stewart,
C.Manoil,
W.C.Van Voorhis.
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ABSTRACT
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Links
