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PDBsum entry 3dko
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Contents |
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* Residue conservation analysis
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PDB id:
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Transferase
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Title:
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Complex between the kinase domain of human ephrin type-a receptor 7 (epha7) and inhibitor alw-ii-49-7
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Structure:
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Ephrin type-a receptor 7. Chain: a. Fragment: kinase domain, unp residues 590-899. Synonym: tyrosine-protein kinase receptor ehk-3, eph homology kinase 3, receptor protein-tyrosine kinase hek11. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Tissue: brain. Gene: epha7, ehk3, hek11. Expressed in: escherichia coli.
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Resolution:
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2.00Å
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R-factor:
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0.191
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R-free:
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0.232
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Authors:
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J.R.Walker,F.Syeda,N.Gray,C.Butler-Cole,C.Bountra,M.Wolkstrom, C.H.Arrowsmith,A.M.Edwards,A.Bochkarev,S.Dhe-Paganon,Structural Genomics Consortium (Sgc)
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Key ref:
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J.R.Walker
et al.
Kinase domain of human ephrin type-A receptor 7 (epha7) in complex with alw-Ii-49-7.
To be published,
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Date:
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25-Jun-08
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Release date:
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19-Aug-08
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PROCHECK
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Headers
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References
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Q15375
(EPHA7_HUMAN) -
Ephrin type-A receptor 7 from Homo sapiens
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Seq:
Struc:
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998 a.a.
275 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 3 residue positions (black
crosses)
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Enzyme class:
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E.C.2.7.10.1
- receptor protein-tyrosine kinase.
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Reaction:
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L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
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L-tyrosyl-[protein]
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+
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ATP
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=
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O-phospho-L-tyrosyl-[protein]
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+
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ADP
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
