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PDBsum entry 3db4
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Contents |
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* Residue conservation analysis
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PDB id:
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Ligase
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Title:
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Crystal structure of the tandem tudor domains of the e3 ubiquitin- protein ligase uhrf1
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Structure:
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E3 ubiquitin-protein ligase uhrf1. Chain: a. Fragment: tandem tudor domains (unp residues 126-285). Synonym: ubiquitin-like phd and ring finger domain-containing protein 1, ubiquitin-like-containing phd and ring finger domains protein 1, inverted ccaat box-binding protein of 90 kda, transcription factor icbp90, nuclear zinc finger protein np95, nuclear protein 95, hunp95, ring finger protein 106. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: uhrf1, icbp90, np95, rnf106. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Resolution:
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2.40Å
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R-factor:
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0.220
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R-free:
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0.285
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Authors:
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J.R.Walker,G.V.Avvakumov,S.Xue,A.Dong,Y.Li,C.Bountra,J.Weigelt, C.H.Arrowsmith,A.M.Edwards,A.Bochkarev,S.Dhe-Paganon,Structural Genomics Consortium (Sgc)
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Key ref:
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N.Nady
et al.
(2011).
Recognition of multivalent histone states associated with heterochromatin by UHRF1 protein.
J Biol Chem,
286,
24300-24311.
PubMed id:
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Date:
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30-May-08
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Release date:
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16-Sep-08
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PROCHECK
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Headers
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References
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Q96T88
(UHRF1_HUMAN) -
E3 ubiquitin-protein ligase UHRF1 from Homo sapiens
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Seq:
Struc:
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793 a.a.
135 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.2.3.2.27
- RING-type E3 ubiquitin transferase.
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Reaction:
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S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6- ubiquitinyl-[acceptor protein]-L-lysine
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J Biol Chem
286:24300-24311
(2011)
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PubMed id:
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Recognition of multivalent histone states associated with heterochromatin by UHRF1 protein.
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N.Nady,
A.Lemak,
J.R.Walker,
G.V.Avvakumov,
M.S.Kareta,
M.Achour,
S.Xue,
S.Duan,
A.Allali-Hassani,
X.Zuo,
Y.X.Wang,
C.Bronner,
F.Chédin,
C.H.Arrowsmith,
S.Dhe-Paganon.
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ABSTRACT
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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S.B.Rothbart,
K.Krajewski,
N.Nady,
W.Tempel,
S.Xue,
A.I.Badeaux,
D.Barsyte-Lovejoy,
J.Y.Martinez,
M.T.Bedford,
S.M.Fuchs,
C.H.Arrowsmith,
and
B.D.Strahl
(2012).
Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation.
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Nat Struct Mol Biol,
19,
1155-1160.
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
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Links
