PDBsum entry 3cxy

Oxidoreductase

PDB id: 3cxy

Contents

Protein chain

393 a.a. *

Ligands

SO4 ×3

HEM

Waters ×726

* Residue conservation analysis

PDB id:

3cxy

Name:

Oxidoreductase

Title:

Crystal structure of the cytochrome p450 cyp121 p346l mutant from m. Tuberculosis

Structure:

Cytochrome p450 121. Chain: a. Synonym: p450 mt2. Engineered: yes. Mutation: yes

Source:

Mycobacterium tuberculosis h37rv. Gene: cyp121. Expressed in: escherichia coli

Resolution:

1.45Å R-factor: 0.154 R-free: 0.186

Authors:

D.Leys

Key ref:

K.J.Mclean et al. Characterization of active site structure in cyp121. To be published, .

Date:

25-Apr-08 Release date: 23-Sep-08

Protein chain

P9WPP7  (CP121_MYCTU) -  Mycocyclosin synthase from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

Seq: 396 a.a.

Struc: 393 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.1.14.19.70 - mycocyclosin synthase.
• Reaction: cyclo(L-tyrosyl-L-tyrosyl) + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H⁺ = mycoclysin + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 H2O
• Cofactor: Heme-thiolate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site