PDBsum entry 3bwc

Transferase

PDB id: 3bwc

Contents

Protein chains

282 a.a. *

Ligands

SAM ×2

BME ×2

Waters ×424

* Residue conservation analysis

PDB id:

3bwc

Name:

Transferase

Title:

Crystal structure of spermidine synthase from trypanosoma cruzi in complex with sam at 2.3 a resolution

Structure:

Spermidine synthase. Chain: a, b. Engineered: yes

Source:

Trypanosoma cruzi. Organism_taxid: 353153. Strain: cl brener. Gene: tc00.1047053510339.50. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.30Å R-factor: 0.206 R-free: 0.259

Authors:

J.Bosch,T.L.Arakaki,I.Le Trong,E.A.Merritt,W.G.J.Hol,Structural Genomics Of Pathogenic Protozoa Consortium (Sgpp)

Key ref:

J.Bosch et al. Crystal structure of spermidine synthase from trypanosoma cruzi.. To be published, .

Date:

09-Jan-08 Release date: 01-Apr-08

Protein chains

Q4DA73  (Q4DA73_TRYCC) -  Spermidine synthase, putative from Trypanosoma cruzi (strain CL Brener)

Seq: 296 a.a.

Struc: 282 a.a.

Enzyme reactions

• Enzyme class: E.C.2.5.1.16 - spermidine synthase.
• Pathway: Spermine Biosynthesis
• Reaction: S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl- 5'-thioadenosine + spermidine + H⁺

S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl- 5'-thioadenosine + spermidine (Bound ligand (Het Group name = SAM) matches with 74.07% similarity) + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site