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PDBsum entry 3b4d
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RNA binding protein
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PDB id
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3b4d
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Contents |
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* Residue conservation analysis
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PDB id:
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RNA binding protein
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Title:
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Crystal structure of human pabpn1 rrm
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Structure:
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Polyadenylate-binding protein 2. Chain: a. Fragment: unp residues 167-254. Synonym: poly(a)-binding protein 2, poly(a)-binding protein ii, pabii, polyadenylate-binding nuclear protein 1, nuclear poly(a)- binding protein 1. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: pabpn1, pab2, pabp2. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
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Resolution:
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2.00Å
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R-factor:
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0.176
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R-free:
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0.207
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Authors:
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H.Ge,S.Tong,M.Teng,L.Niu
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Key ref:
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H.Ge
et al.
(2008).
Crystal structure and possible dimerization of the single RRM of human PABPN1.
Proteins,
71,
1539-1545.
PubMed id:
DOI:
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Date:
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24-Oct-07
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Release date:
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15-Jan-08
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PROCHECK
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Headers
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References
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Q86U42
(PABP2_HUMAN) -
Polyadenylate-binding protein 2 from Homo sapiens
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Seq:
Struc:
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306 a.a.
80 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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DOI no:
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Proteins
71:1539-1545
(2008)
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PubMed id:
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Crystal structure and possible dimerization of the single RRM of human PABPN1.
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H.Ge,
D.Zhou,
S.Tong,
Y.Gao,
M.Teng,
L.Niu.
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ABSTRACT
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Selected figure(s)
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Figure 3.
Figure 3. Dimer interactions of PABPN1 RRM. (a) Two-dimensional
plots give an overview of the mode of dimerization in PABPN1 RRM
crystal structure. Sticks diagrams show (b) the residues on  2
strand in one monomer forms main chain hydrogen bonds with the
2
strand in the neighboring monomer in an antiparallel fashion,
and (c) some residues on loop1 and  1
provide additional dimeric forces. The relevant residues are
labeled in (b) and (c).
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Figure 4.
Figure 4. Stereo ribbon figure showing the superposition of
PABPN1 RRM (green) and the U2B  RRM
(orange) bound to a fragment (5  -[6]AUUGCAGUACC[16]-3
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of U2 snRNA.
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The above figures are
reprinted
by permission from John Wiley & Sons, Inc.:
Proteins
(2008,
71,
1539-1545)
copyright 2008.
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Figures were
selected
by an automated process.
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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B.Brais
(2009).
Oculopharyngeal muscular dystrophy: a polyalanine myopathy.
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Curr Neurol Neurosci Rep,
9,
76-82.
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J.P.Tavanez,
R.Bengoechea,
M.T.Berciano,
M.Lafarga,
M.Carmo-Fonseca,
and
F.J.Enguita
(2009).
Hsp70 chaperones and type I PRMTs are sequestered at intranuclear inclusions caused by polyalanine expansions in PABPN1.
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PLoS One,
4,
e6418.
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
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Links
