PDBsum entry 3zr0

Hydrolase

PDB id: 3zr0

Contents

Protein chain

154 a.a.

Ligands

8OG ×2

SO4 ×5

Waters ×201

PDB id:

3zr0

Name:

Hydrolase

Title:

Crystal structure of human mth1 in complex with 8-oxo-dgmp

Structure:

7,8-dihydro-8-oxoguanine triphosphatase. Chain: a, b. Synonym: mth1,8-oxo-dgtpase, nucleoside diphosphate-linked moiety x motif 1, nudix motif 1. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: nudt1. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

1.80Å R-factor: 0.199 R-free: 0.246

Authors:

L.M.Svensson,A.Jemth,M.Desroses,O.Loseva,T.Helleday,M.Hogbom, P.Stenmark

Key ref:

L.M.Svensson et al. (2011). Crystal structure of human MTH1 and the 8-oxo-dGMP product complex. Febs Lett, 585, 2617-2621. PubMed id: 21787772

Date:

13-Jun-11 Release date: 27-Jul-11

Protein chains

P36639  (8ODP_HUMAN) -  Oxidized purine nucleoside triphosphate hydrolase from Homo sapiens

Seq: 156 a.a.

Struc: 154 a.a.

Enzyme reactions

• Enzyme class 2: E.C.3.6.1.- - ?????
• Enzyme class 3: E.C.3.6.1.56 - 2-hydroxy-dATP diphosphatase.
• Reaction: 2-oxo-dATP + H2O = 2-oxo-dAMP + diphosphate + H⁺

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Key reference

Febs Lett 585:2617-2621 (2011)

PubMed id: 21787772

Crystal structure of human MTH1 and the 8-oxo-dGMP product complex.

L.M.Svensson, A.S.Jemth, M.Desroses, O.Loseva, T.Helleday, M.Högbom, P.Stenmark.

ABSTRACT

No abstract given.