PDBsum entry 3w7e

Oxidoreductase/oxidoreductase inhibitor

PDB id: 3w7e

Contents

Protein chains

313 a.a.

Ligands

W7F ×2

GOL ×21

FMN ×2

NCO

Waters ×677

PDB id:

3w7e

Name:

Oxidoreductase/oxidoreductase inhibitor

Title:

Structure of trypanosoma cruzi dihydroorotate dehydrogenase in complex with mii-5-179

Structure:

Dihydroorotate dehydrogenase (fumarate). Chain: a, b. Synonym: dhod, dhodase, dhodehase, dihydroorotate oxidase. Engineered: yes

Source:

Trypanosoma cruzi. Organism_taxid: 353153. Strain: cl brener. Gene: pyrd. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.56Å R-factor: 0.143 R-free: 0.173

Authors:

D.K.Inaoka,M.Iida,T.Tabuchi,N.Lee,S.Hashimoto,S.Matsuoka,T.Kuranaga, T.Shiba,K.Sakamoto,S.Suzuki,E.O.Balogun,T.Nara,T.Aoki,M.Inoue, T.Honma,A.Tanaka,S.Harada,K.Kita

Key ref:

D.K.Inaoka et al. Structure of trypanosoma cruzi dihydroorotate dehydro in complex with mii-5-179. To be published, .

Date:

28-Feb-13 Release date: 05-Mar-14

Protein chains

Q4D3W2  (PYRD_TRYCC) -  Dihydroorotate dehydrogenase (fumarate) from Trypanosoma cruzi (strain CL Brener)

Seq: 314 a.a.

Struc: 313 a.a.

Enzyme reactions

• Enzyme class: E.C.1.3.98.1 - dihydroorotate oxidase (fumarate).
• Reaction: (S)-dihydroorotate + fumarate = orotate + succinate

(S)-dihydroorotate (Bound ligand (Het Group name = W7F) matches with 44.00% similarity) + fumarate (Bound ligand (Het Group name = GOL) matches with 40.00% similarity) = orotate + succinate

• Cofactor: FMN

FMN (Bound ligand (Het Group name = FMN) corresponds exactly)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site