PDBsum entry 3vnn

Ligase

PDB id: 3vnn

Contents

Protein chain

124 a.a.

Waters ×3

PDB id:

3vnn

Name:

Ligase

Title:

Crystal structure of a sub-domain of the nucleotidyltransferase (adenylation) domain of human DNA ligase iv

Structure:

DNA ligase 4. Chain: a. Fragment: a sub-domain of the nucleotidyltransferase (adenylation) domain, unp residues 268-405. Synonym: DNA ligase iv, polydeoxyribonucleotide synthase [atp] 4. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: lig4. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.90Å R-factor: 0.277 R-free: 0.305

Authors:

T.Ochi,Q.Wu,D.Y.Chirgadze,J.G.Grossmann,V.M.Bolanos-Garcia, T.L.Blundell

Key ref:

T.Ochi et al. (2012). Structural insights into the role of domain flexibility in human DNA ligase IV. Structure, 20, 1212-1222. PubMed id: 22658747

Date:

17-Jan-12 Release date: 20-Jun-12

Protein chain

P49917  (DNLI4_HUMAN) -  DNA ligase 4 from Homo sapiens

Seq: 911 a.a.

Struc: 124 a.a.

Enzyme reactions

• Enzyme class: E.C.6.5.1.1 - Dna ligase (ATP).
• Reaction: ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho- (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

Structure 20:1212-1222 (2012)

PubMed id: 22658747

Structural insights into the role of domain flexibility in human DNA ligase IV.

T.Ochi, Q.Wu, D.Y.Chirgadze, J.G.Grossmann, V.M.Bolanos-Garcia, T.L.Blundell.

ABSTRACT

No abstract given.