PDBsum entry 3v6b

Hormone/signaling protein

PDB id

3v6b

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Contents

			Protein chains

					94 a.a.


					187 a.a.

PDB id:

3v6b

Links

Name:

Hormone/signaling protein

Title:

Vegfr-2/vegf-e complex structure

Structure:

Vegf-e. Chain: a. Fragment: vegf-e, unp residues 21-133. Engineered: yes. Vascular endothelial growth factor receptor 2. Chain: r. Fragment: vegfr-2, unp residues 132-548. Synonym: vegfr-2, fetal liver kinase 1, flk-1, kinase insert domain receptor, kdr, protein-tyrosine kinase receptor flk-1.

Source:

Orf virus. Orfv. Organism_taxid: 10258. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Homo sapiens. Human. Organism_taxid: 9606. Gene: kdr, flk1, vegfr2.

Resolution:

3.21Å

R-factor:

0.239

R-free:

0.276

Authors:

M.S.Brozzo,V.-M.Leppanen,F.K.Winkler,K.Kisko,K.Ballmer-Hofer

Key ref:

M.S.Brozzo et al. (2012). Thermodynamic and structural description of allosterically regulated VEGFR-2 dimerization. Blood, 119, 1781-1788. PubMed id: 22207738

Date:

19-Dec-11

Release date:

18-Jan-12

PROCHECK

	Headers

	References

Protein chain

P52584 (VEGFH_ORFN2) - Vascular endothelial growth factor homolog from Orf virus (strain NZ2)

Seq: Struc:					133 a.a. 94 a.a.*

Protein chain

P35968 (VGFR2_HUMAN) - Vascular endothelial growth factor receptor 2 from Homo sapiens

Seq: Struc:

Seq: Struc:

Seq: Struc:					1356 a.a. 187 a.a.*

Key:

PfamA domain

Secondary structure

CATH domain

* PDB and UniProt seqs differ at 2 residue positions (black crosses)



		Enzyme reactions

Enzyme class:

Chain R: E.C.2.7.10.1 - receptor protein-tyrosine kinase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

L-tyrosyl-[protein]	+	ATP	=	O-phospho-L-tyrosyl-[protein]	+	ADP	+	H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

	Blood 119:1781-1788 (2012)
PubMed id: 22207738

Thermodynamic and structural description of allosterically regulated VEGFR-2 dimerization.
M.S.Brozzo, S.Bjelić, K.Kisko, T.Schleier, V.M.Leppänen, K.Alitalo, F.K.Winkler, K.Ballmer-Hofer.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

23076159

K.Verstraete, and S.N.Savvides (2012).
Extracellular assembly and activation principles of oncogenic class III receptor tyrosine kinases.

Nat Rev Cancer, 12, 753-766.

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.