PDBsum entry 3upt

Transferase

PDB id

3upt

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Contents

			Protein chains

					671 a.a.

			Ligands

					TPP ×2


					RP5 ×2

			Metals

					_BR ×4


					_CA ×2

			Waters ×821

PDB id:

3upt

Links

Name:

Transferase

Title:

Crystal structure of a transketolase from burkholderia pseudomallei bound to tpp, calcium and ribose-5-phosphate

Structure:

Transketolase. Chain: a, b. Engineered: yes

Source:

Burkholderia thailandensis. Organism_taxid: 271848. Strain: e264 / atcc 700388 / dsm 13276 / cip 106301. Gene: bth_i1195, tkt. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.40Å

R-factor:

0.153

R-free:

0.200

Authors:

Seattle Structural Genomics Center For Infectious Disease (Ssgcid)

Key ref:

L.Baugh et al. (2013). Combining functional and structural genomics to sample the essential Burkholderia structome. Plos One, 8, e53851. PubMed id: 23382856

Date:

18-Nov-11

Release date:

14-Dec-11

PROCHECK

	Headers

	References

Protein chains

Q2SZA7 (Q2SZA7_BURTA) - transketolase from Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264)

Seq: Struc:

Seq: Struc:					690 a.a. 671 a.a.

Key:

PfamA domain

Secondary structure

CATH domain



		Enzyme reactions

Enzyme class:

E.C.2.2.1.1 - transketolase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D- ribose 5-phosphate + D-xylulose 5-phosphate

D-sedoheptulose 7-phosphate

D-glyceraldehyde 3-phosphate

aldehydo-D- ribose 5-phosphate

D-xylulose 5-phosphate
Bound ligand (Het Group name = RP5)
corresponds exactly

Cofactor:

Thiamine diphosphate

Thiamine diphosphate
Bound ligand (Het Group name = TPP) corresponds exactly

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

	Plos One 8:e53851 (2013)
PubMed id: 23382856

Combining functional and structural genomics to sample the essential Burkholderia structome.
L.Baugh, L.A.Gallagher, R.Patrapuvich, M.C.Clifton, A.S.Gardberg, T.E.Edwards, B.Armour, D.W.Begley, S.H.Dieterich, D.M.Dranow, J.Abendroth, J.W.Fairman, D.Fox, B.L.Staker, I.Phan, A.Gillespie, R.Choi, S.Nakazawa-Hewitt, M.T.Nguyen, A.Napuli, L.Barrett, G.W.Buchko, R.Stacy, P.J.Myler, L.J.Stewart, C.Manoil, W.C.Van Voorhis.

ABSTRACT

No abstract given.