PDBsum entry 3uih

Apoptosis/apoptosis inhibitor

PDB id

3uih

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Contents

			Protein chains

					136 a.a.

			Ligands

					ALA-VAL-PRO-ILE ×2

			Metals

					_ZN ×2

			Waters ×23

PDB id:

3uih

Links

Name:

Apoptosis/apoptosis inhibitor

Title:

Crystal structure of human survivin in complex with smac/diablo(1-15) peptide

Structure:

Baculoviral iap repeat-containing protein 5. Chain: a, b. Fragment: unp residues 1-142. Synonym: apoptosis inhibitor 4, apoptosis inhibitor survivin. Engineered: yes. Mutation: yes. Diablo homolog, mitochondrial. Chain: p, q. Fragment: unp residues 1-15.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: birc5, api4, iap4. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Organism_taxid: 9606

Resolution:

2.40Å

R-factor:

0.211

R-free:

0.245

Authors:

J.Du,D.J.Patel

Key ref:

J.Du et al. (2012). Structural basis for recognition of H3T3ph and Smac/DIABLO N-terminal peptides by human Survivin. Structure, 20, 185-195. PubMed id: 22244766

Date:

04-Nov-11

Release date:

01-Feb-12

PROCHECK

	Headers

	References

Protein chains

O15392 (BIRC5_HUMAN) - Baculoviral IAP repeat-containing protein 5 from Homo sapiens

Seq: Struc:					142 a.a. 136 a.a.

Key:

PfamA domain

Secondary structure

CATH domain

	Structure 20:185-195 (2012)
PubMed id: 22244766

Structural basis for recognition of H3T3ph and Smac/DIABLO N-terminal peptides by human Survivin.
J.Du, A.E.Kelly, H.Funabiki, D.J.Patel.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

23211769

C.A.Musselman, M.E.Lalonde, J.Côté, and T.G.Kutateladze (2012).
Perceiving the epigenetic landscape through histone readers.

Nat Struct Mol Biol, 19, 1218-1227.

23175282

M.Carmena, M.Wheelock, H.Funabiki, and W.C.Earnshaw (2012).
The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis.

Nat Rev Mol Cell Biol, 13, 789-803.

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.