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PDBsum entry 3u4b

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protein Protein-protein interface(s) links
Immune system PDB id
3u4b

 

 

 

 

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Contents
Protein chains
227 a.a.
214 a.a.
Waters ×38
PDB id:
3u4b
Name: Immune system
Title: Ch04h/ch02l fab p4
Structure: Ch04 heavy chain. Chain: h. Engineered: yes. Ch02 light chain. Chain: l. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_taxid: 9606
Resolution:
2.89Å     R-factor:   0.224     R-free:   0.268
Authors: M.Pancera,R.Louder,J.S.Mclellan,P.D.Kwong
Key ref: J.S.McLellan et al. (2011). Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9. Nature, 480, 336-343. PubMed id: 22113616
Date:
07-Oct-11     Release date:   30-Nov-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
No UniProt id for this chain
Struc: 227 a.a.
Protein chain
No UniProt id for this chain
Struc: 214 a.a.
Key:    Secondary structure  CATH domain

 

 
Nature 480:336-343 (2011)
PubMed id: 22113616  
 
 
Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9.
J.S.McLellan, M.Pancera, C.Carrico, J.Gorman, J.P.Julien, R.Khayat, R.Louder, R.Pejchal, M.Sastry, K.Dai, S.O'Dell, N.Patel, S.Shahzad-ul-Hussan, Y.Yang, B.Zhang, T.Zhou, J.Zhu, J.C.Boyington, G.Y.Chuang, D.Diwanji, I.Georgiev, Y.D.Kwon, D.Lee, M.K.Louder, S.Moquin, S.D.Schmidt, Z.Y.Yang, M.Bonsignori, J.A.Crump, S.H.Kapiga, N.E.Sam, B.F.Haynes, D.R.Burton, W.C.Koff, L.M.Walker, S.Phogat, R.Wyatt, J.Orwenyo, L.X.Wang, J.Arthos, C.A.Bewley, J.R.Mascola, G.J.Nabel, W.R.Schief, A.B.Ward, I.A.Wilson, P.D.Kwong.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
22982990 D.C.Ekiert, A.K.Kashyap, J.Steel, A.Rubrum, G.Bhabha, R.Khayat, J.H.Lee, M.A.Dillon, R.E.O'Neil, A.M.Faynboym, M.Horowitz, L.Horowitz, A.B.Ward, P.Palese, R.Webby, R.A.Lerner, R.R.Bhatt, and I.A.Wilson (2012).
Cross-neutralization of influenza A viruses mediated by a single antibody loop.
  Nature, 489, 526-532.
PDB codes: 4fnk 4fnl 4fp8 4fqr
23103874 F.Klein, A.Halper-Stromberg, J.A.Horwitz, H.Gruell, J.F.Scheid, S.Bournazos, H.Mouquet, L.A.Spatz, R.Diskin, A.Abadir, T.Zang, M.Dorner, E.Billerbeck, R.N.Labitt, C.Gaebler, P.M.Marcovecchio, R.B.Incesu, T.R.Eisenreich, P.D.Bieniasz, M.S.Seaman, P.J.Bjorkman, J.V.Ravetch, A.Ploss, and M.C.Nussenzweig (2012).
HIV therapy by a combination of broadly neutralizing antibodies in humanized mice.
  Nature, 492, 118-122.  
22960785 M.Rolland, P.T.Edlefsen, B.B.Larsen, S.Tovanabutra, E.Sanders-Buell, T.Hertz, A.C.deCamp, C.Carrico, S.Menis, C.A.Magaret, H.Ahmed, M.Juraska, L.Chen, P.Konopa, S.Nariya, J.N.Stoddard, K.Wong, H.Zhao, W.Deng, B.S.Maust, M.Bose, S.Howell, A.Bates, M.Lazzaro, A.O'Sullivan, E.Lei, A.Bradfield, G.Ibitamuno, V.Assawadarachai, R.J.O'Connell, M.S.deSouza, S.Nitayaphan, S.Rerks-Ngarm, M.L.Robb, J.S.McLellan, I.Georgiev, P.D.Kwong, J.M.Carlson, N.L.Michael, W.R.Schief, P.B.Gilbert, J.I.Mullins, and J.H.Kim (2012).
Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2.
  Nature, 490, 417-420.  
23007571 P.C.Wilson, and S.F.Andrews (2012).
Tools to therapeutically harness the human antibody response.
  Nat Rev Immunol, 12, 709-719.  
23154260 P.R.Dormitzer, G.Grandi, and R.Rappuoli (2012).
Structural vaccinology starts to deliver.
  Nat Rev Microbiol, 10, 807-813.  
22864288 Y.Mao, L.Wang, C.Gu, A.Herschhorn, S.H.Xiang, H.Haim, X.Yang, and J.Sodroski (2012).
Subunit organization of the membrane-bound HIV-1 envelope glycoprotein trimer.
  Nat Struct Mol Biol, 19, 893-899.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB codes are shown on the right.

 

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